Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer
Blumea balsamifera (Bb) is a plant used as herbal medicine in Southeast Asia, and it has been used due to its antibacterial, antiinflammatory, anticancer, etc. However, there is currently limited evidence that Bb leaf extract from Batu, Indonesia, contains beneficial compounds against breast cancer....
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03004.pdf |
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| author | Kamila Fairuz Sarah Annisa Yuslinda Rosyadah Nuraini Hermanto Feri Eko Widyananda Muhammad Hermawan Dwijayanti Dinia Rizqi Widodo Nashi |
| author_facet | Kamila Fairuz Sarah Annisa Yuslinda Rosyadah Nuraini Hermanto Feri Eko Widyananda Muhammad Hermawan Dwijayanti Dinia Rizqi Widodo Nashi |
| author_sort | Kamila Fairuz Sarah |
| collection | DOAJ |
| description | Blumea balsamifera (Bb) is a plant used as herbal medicine in Southeast Asia, and it has been used due to its antibacterial, antiinflammatory, anticancer, etc. However, there is currently limited evidence that Bb leaf extract from Batu, Indonesia, contains beneficial compounds against breast cancer. Hence, this study evaluates the active compounds in extract and their potential as therapeutic agents for breast cancer. The total phenolic and flavonoid content was determined based on quantified colourimetry analysis followed by DPPH assay to evaluate antioxidant activity and phytochemicals screening in the extract, which was characterised by LC-HRMS analysis. Furthermore, computational methods are used to predict the pharmacological properties of compounds in the extract, particularly against breast cancer. The results showed a total phenolic content of 103.85+1.5 mgGAE/g and a total flavonoid content of 225.99+17.68 mgQE/g, with an antioxidant activity of 255.17+13.11µg/mL. 11 compounds were identified, but only four (Aurantio-obtusin, Isorhamnetin, Quercetin, and Hemiphloin) were computationally analysed. Molecular docking and dynamics simulation indicate that these phytochemicals bind to their target, possibly limiting their activity. Therefore, Bb has potential as a natural product remedy for breast cancer and contributes significantly to our knowledge of the plant by providing essential data for its future development. |
| format | Article |
| id | doaj-art-3ef8c041053e41ed8c6085de37f8ab7e |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-3ef8c041053e41ed8c6085de37f8ab7e2025-02-05T10:43:07ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011540300410.1051/bioconf/202515403004bioconf_icgrc2025_03004Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancerKamila Fairuz Sarah0Annisa Yuslinda1Rosyadah Nuraini2Hermanto Feri Eko3Widyananda Muhammad Hermawan4Dwijayanti Dinia Rizqi5Widodo Nashi6Biology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaBiology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaBiology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaFaculty of Animal Sciences, Universitas BrawijayaBiology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaBiology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaBiology Department, Faculty of Mathematics and Natural Sciences, Universitas BrawijayaBlumea balsamifera (Bb) is a plant used as herbal medicine in Southeast Asia, and it has been used due to its antibacterial, antiinflammatory, anticancer, etc. However, there is currently limited evidence that Bb leaf extract from Batu, Indonesia, contains beneficial compounds against breast cancer. Hence, this study evaluates the active compounds in extract and their potential as therapeutic agents for breast cancer. The total phenolic and flavonoid content was determined based on quantified colourimetry analysis followed by DPPH assay to evaluate antioxidant activity and phytochemicals screening in the extract, which was characterised by LC-HRMS analysis. Furthermore, computational methods are used to predict the pharmacological properties of compounds in the extract, particularly against breast cancer. The results showed a total phenolic content of 103.85+1.5 mgGAE/g and a total flavonoid content of 225.99+17.68 mgQE/g, with an antioxidant activity of 255.17+13.11µg/mL. 11 compounds were identified, but only four (Aurantio-obtusin, Isorhamnetin, Quercetin, and Hemiphloin) were computationally analysed. Molecular docking and dynamics simulation indicate that these phytochemicals bind to their target, possibly limiting their activity. Therefore, Bb has potential as a natural product remedy for breast cancer and contributes significantly to our knowledge of the plant by providing essential data for its future development.https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03004.pdf |
| spellingShingle | Kamila Fairuz Sarah Annisa Yuslinda Rosyadah Nuraini Hermanto Feri Eko Widyananda Muhammad Hermawan Dwijayanti Dinia Rizqi Widodo Nashi Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer BIO Web of Conferences |
| title | Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer |
| title_full | Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer |
| title_fullStr | Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer |
| title_full_unstemmed | Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer |
| title_short | Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer |
| title_sort | evaluation of polyphenol and antioxidant properties of blumea balsamifera extract as potential therapeutic for breast cancer |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03004.pdf |
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