Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell metabolism

Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell metabolism

Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited responses to standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with obesity, its anatomical location surrounded by visceral adipose tissue has been postulated to...

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Bibliographic Details
Main Authors: Fiona O'Connell, Eimear Mylod, Noel E. Donlon, Maria Davern, Christine Butler, Niamh O'Connor, Meghana S. Menon, Claire L. Donohoe, Narayanasamy Ravi, Derek G. Doherty, Margaret R. Dunne, John V. Reynolds, Helen M. Roche, Jacintha O'Sullivan
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Translational Oncology
Subjects:
Oesophageal adenocarcinoma
Adipose tissue metabolism
Chemotherapy
Chemoradiotherapy
Myeloid immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000336
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