ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY
Purpose of the study – to assess the content of cytokines IL-8, IL-1b and MCP-1 in the first trimester of pregnancy in women with chronic arterial hypertension. Materials and methods. The study included patients aged 18-45 years at 10-13 weeks of pregnancy. The main group – 46 pregnant women with c...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
The Publishing House Medicine and Enlightenment
2024-11-01
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| Series: | Мать и дитя в Кузбассе |
| Subjects: | |
| Online Access: | https://mednauki.ru/index.php/MD/article/view/1147 |
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| Summary: | Purpose of the study – to assess the content of cytokines IL-8, IL-1b and MCP-1 in the first trimester of pregnancy in women with chronic arterial hypertension.
Materials and methods. The study included patients aged 18-45 years at 10-13 weeks of pregnancy. The main group – 46 pregnant women with chronic arterial hypertension (stage I hypertension), the control group – 30 healthy pregnant women. Cytokine levels were determined by enzyme-linked immunosorbent assay.
Results. The results of the study revealed that women with chronic arterial hypertension had statistically significantly lower levels of IL-8 and MCP-1. It has been established that in order to maintain trophoblast function, inflammatory processes in the intervillous space are weakened.
Conclusion. The cytokine MCP-1 can be considered as a marker of the development of preeclampsia. Further study of its significance is necessary in a larger sample of patients and in correlation with other markers. |
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| ISSN: | 1991-010X 2542-0968 |