MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions

MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions

Abstract Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to various age-related pathologies including neurodegeneration, atherosclerosis and male reproduc...

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Main Authors: Shene Chiou, Wayne Cawthorne, Thomas Soerianto, Vinzenz Hofferek, Komal M. Patel, Sarah E. Garnish, Emma C. Tovey Crutchfield, Cathrine Hall, Joanne M. Hildebrand, Malcolm J. McConville, Kate E. Lawlor, Edwin D. Hawkins, Andre L. Samson, James M. Murphy
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07242-z
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https://doi.org/10.1038/s41419-024-07242-z

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