A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

ABSTRACT Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here, we identify and characterize a class of human antibodies th...

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Bibliographic Details
Main Authors: Holly C. Simmons, Joel Finney, Ryutaro Kotaki, Yu Adachi, Annie Park Moseman, Akiko Watanabe, Shengli Song, Lindsey R. Robinson-McCarthy, Valerie Le Sage, Masayuki Kuraoka, E. Ashley Moseman, Garnett Kelsoe, Yoshimasa Takahashi, Kevin R. McCarthy
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
influenza
monoclonal antibodies
antibody repertoire
virology
protein structure-function
immunology
Online Access:https://journals.asm.org/doi/10.1128/mbio.00892-25
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