Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography
Background: To assess the diagnostic performance of contrast-enhanced mammography (CEM) in screening higher-risk Taiwanese women for breast cancer. Methods: We conducted a prospective study at a Taiwanese medical center from 2019 to 2021. The study compared imaging techniques for breast cancer scree...
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Elsevier
2025-01-01
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| author | Chen-Pin Chou Yu-Ting Hong Yun Lin Pei-Ying Lin |
| author_facet | Chen-Pin Chou Yu-Ting Hong Yun Lin Pei-Ying Lin |
| author_sort | Chen-Pin Chou |
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| description | Background: To assess the diagnostic performance of contrast-enhanced mammography (CEM) in screening higher-risk Taiwanese women for breast cancer. Methods: We conducted a prospective study at a Taiwanese medical center from 2019 to 2021. The study compared imaging techniques for breast cancer screening in women with a personal history of precancer or cancer, or a family history (first-degree relatives). The study included breast ultrasound (US) and the CEM combo, which consists of digital mammography (DM), digital breast tomosynthesis (DBT), and CEM. Diagnostic accuracy was compared using the receiver operating characteristic (ROC) curve. Results: The study included 308 women, average age 52.1, with 86 % having familial breast cancer history and 14 % personal breast cancer or pre-cancerous histories. Approximately 19.5 % had lesions rated BI-RADS 4 or 5. Biopsies were performed on 56 women based on lesions detected by the CEM combo. Additionally, 60 biopsies were due to abnormalities found via DM or DBT (n = 20) or US (n = 40). Breast cancer was confirmed in 8 women post-biopsy. The CEM combo showed a sensitivity of 87.5 %, significantly higher than DM (50 %), DBT (50 %), and US (25 %). The ROC curve area for CEM was 0.85, outperforming DM (0.65), DBT (0.63), and US (0.55), with all comparisons statistically significant (p < 0.05). Lesions detected solely by DM, DBT, or US did not yield any cancer cases. Conclusions: CEM effectively detects breast cancer in higher-risk Taiwanese women, but further research is needed to refine biopsy recommendations. |
| format | Article |
| id | doaj-art-3e66cb2d41e2423e95323a399ae2e6a6 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| spelling | doaj-art-3e66cb2d41e2423e95323a399ae2e6a62025-02-02T05:28:23ZengElsevierHeliyon2405-84402025-01-01112e41851Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammographyChen-Pin Chou0Yu-Ting Hong1Yun Lin2Pei-Ying Lin3Radiology Department, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC; Department of Medical Laboratory Science and Biotechnology, Fooyin University, Kaohsiung, Taiwan, ROC; Department of Pharmacy, College of Pharmacy, Tajen University, Pingtung, Taiwan, ROC; Corresponding author. Radiology Department, Kaohsiung Veteran General Hospital 386 Ta-Chung 1st Rd., Kaohsiung 813, Taiwan, ROC.Radiology Department, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROCRadiology Department, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROCRadiology Department, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROCBackground: To assess the diagnostic performance of contrast-enhanced mammography (CEM) in screening higher-risk Taiwanese women for breast cancer. Methods: We conducted a prospective study at a Taiwanese medical center from 2019 to 2021. The study compared imaging techniques for breast cancer screening in women with a personal history of precancer or cancer, or a family history (first-degree relatives). The study included breast ultrasound (US) and the CEM combo, which consists of digital mammography (DM), digital breast tomosynthesis (DBT), and CEM. Diagnostic accuracy was compared using the receiver operating characteristic (ROC) curve. Results: The study included 308 women, average age 52.1, with 86 % having familial breast cancer history and 14 % personal breast cancer or pre-cancerous histories. Approximately 19.5 % had lesions rated BI-RADS 4 or 5. Biopsies were performed on 56 women based on lesions detected by the CEM combo. Additionally, 60 biopsies were due to abnormalities found via DM or DBT (n = 20) or US (n = 40). Breast cancer was confirmed in 8 women post-biopsy. The CEM combo showed a sensitivity of 87.5 %, significantly higher than DM (50 %), DBT (50 %), and US (25 %). The ROC curve area for CEM was 0.85, outperforming DM (0.65), DBT (0.63), and US (0.55), with all comparisons statistically significant (p < 0.05). Lesions detected solely by DM, DBT, or US did not yield any cancer cases. Conclusions: CEM effectively detects breast cancer in higher-risk Taiwanese women, but further research is needed to refine biopsy recommendations.http://www.sciencedirect.com/science/article/pii/S2405844025002312Breast cancerMammographyContrast-enhanced mammographyHigher-riskBI-RADS category |
| spellingShingle | Chen-Pin Chou Yu-Ting Hong Yun Lin Pei-Ying Lin Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography Heliyon Breast cancer Mammography Contrast-enhanced mammography Higher-risk BI-RADS category |
| title | Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography |
| title_full | Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography |
| title_fullStr | Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography |
| title_full_unstemmed | Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography |
| title_short | Screening of breast cancer in higher-risk Taiwanese women using contrast-enhanced mammography |
| title_sort | screening of breast cancer in higher risk taiwanese women using contrast enhanced mammography |
| topic | Breast cancer Mammography Contrast-enhanced mammography Higher-risk BI-RADS category |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002312 |
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