Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases

There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity. An HIV-1-RNase H assay was used to study the RNase H inhibition by the test compounds. Docking of active derivatives i...

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Main Authors: Nhat Quang Tu, Clémence Richetta, Federica Putzu, Olivier Delelis, Khursheed Ahmed, Vijay H. Masand, Rainer Schobert, Enzo Tramontano, Angela Corona, Bernhard Biersack
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
naphthoquinone
lawsone
antiviral drugs
HIV
RNase H
SARS-CoV-2
Online Access:https://www.mdpi.com/1420-3049/30/3/495
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