Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome
Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles in...
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2024-12-01
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| author | Éllen F. Rodrigues Flavia Alves Verza Felipe Garcia Nishimura Renê Oliveira Beleboni Cedric Hermans Kaat Janssens Maarten Lieven De Mol Paco Hulpiau Mozart Marins |
| author_facet | Éllen F. Rodrigues Flavia Alves Verza Felipe Garcia Nishimura Renê Oliveira Beleboni Cedric Hermans Kaat Janssens Maarten Lieven De Mol Paco Hulpiau Mozart Marins |
| author_sort | Éllen F. Rodrigues |
| collection | DOAJ |
| description | Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles in the physiological and developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, and lead molecules for anticancer, antidiabetic, and antimicrobial drugs. Lectins from Rhodophytes (red seaweed) have been extensively reported and characterized for their unique molecular structures, carbohydrate-binding specificities, and important biological activities. The increasing number of sequenced Rhodophyte genomes offers the opportunity to further study this rich source of lectins, potentially uncovering new ones with properties significantly different from their terrestrial plant counterparts, thus opening new biotechnological applications. We compiled literature data and conducted an in-depth analysis of the phycolectomes from all Rhodophyta genomes available in NCBI datasets. Using Hidden Markov Models capable of identifying lectin-type domains, we found at least six different types of lectin domains present in Rhodophytes, demonstrating their potential in identifying new lectins. This review integrates a computational analysis of the Rhodophyte phycolectome with existing information on red algae lectins and their biotechnological potential. |
| format | Article |
| id | doaj-art-3e0f1155544f4268b64dea79f4119744 |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-3e0f1155544f4268b64dea79f41197442025-01-24T13:39:26ZengMDPI AGMarine Drugs1660-33972024-12-01231810.3390/md23010008Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte PhycolectomeÉllen F. Rodrigues0Flavia Alves Verza1Felipe Garcia Nishimura2Renê Oliveira Beleboni3Cedric Hermans4Kaat Janssens5Maarten Lieven De Mol6Paco Hulpiau7Mozart Marins8Postgraduate Program in Environmental Technology, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, BrazilBiotechnology Unit, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, BrazilBiotechnology Unit, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, BrazilBiotechnology Unit, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, BrazilBioinformatics Knowledge Center (BiKC), Cluster Life Sciences, Campus Brugge Station, Howest University of Applied Sciences, Spoorwegstraat 4, 8200 Brugge, BelgiumBioinformatics Knowledge Center (BiKC), Cluster Life Sciences, Campus Brugge Station, Howest University of Applied Sciences, Spoorwegstraat 4, 8200 Brugge, BelgiumCentre for Industrial Biotechnology and Biocatalysis (InBio.be), Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, BelgiumBioinformatics Knowledge Center (BiKC), Cluster Life Sciences, Campus Brugge Station, Howest University of Applied Sciences, Spoorwegstraat 4, 8200 Brugge, BelgiumBiotechnology Unit, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, BrazilLectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles in the physiological and developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, and lead molecules for anticancer, antidiabetic, and antimicrobial drugs. Lectins from Rhodophytes (red seaweed) have been extensively reported and characterized for their unique molecular structures, carbohydrate-binding specificities, and important biological activities. The increasing number of sequenced Rhodophyte genomes offers the opportunity to further study this rich source of lectins, potentially uncovering new ones with properties significantly different from their terrestrial plant counterparts, thus opening new biotechnological applications. We compiled literature data and conducted an in-depth analysis of the phycolectomes from all Rhodophyta genomes available in NCBI datasets. Using Hidden Markov Models capable of identifying lectin-type domains, we found at least six different types of lectin domains present in Rhodophytes, demonstrating their potential in identifying new lectins. This review integrates a computational analysis of the Rhodophyte phycolectome with existing information on red algae lectins and their biotechnological potential.https://www.mdpi.com/1660-3397/23/1/8Rhodophytared seaweedphycolectomelectins |
| spellingShingle | Éllen F. Rodrigues Flavia Alves Verza Felipe Garcia Nishimura Renê Oliveira Beleboni Cedric Hermans Kaat Janssens Maarten Lieven De Mol Paco Hulpiau Mozart Marins Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome Marine Drugs Rhodophyta red seaweed phycolectome lectins |
| title | Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome |
| title_full | Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome |
| title_fullStr | Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome |
| title_full_unstemmed | Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome |
| title_short | Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome |
| title_sort | exploring the structural diversity and biotechnological potential of the rhodophyte phycolectome |
| topic | Rhodophyta red seaweed phycolectome lectins |
| url | https://www.mdpi.com/1660-3397/23/1/8 |
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