Aurantio-obtusin modulates Wilms Tumour 1 within the breast tumour microenvironment reducing immunosuppression and tumour growth

Aurantio-obtusin modulates Wilms Tumour 1 within the breast tumour microenvironment reducing immunosuppression and tumour growth

Abstract Introduction Cancer associated fibroblasts (CAFs) contribute to tumourigenesis and immune tolerance within the tumour microenvironment (TME). Therefore, inhibiting the pro-tumourigenic function of CAFs can be a viable therapeutic approach. However, targeting CAFs is challenging due to the l...

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Main Authors: Rui Li, Dómhnall J O’Connor, Barry Digby, Pilib Ó. Broin, Xiao Hu, Ning Ge, Paul G. Loftus, Vatsal Kumar, Eoin McEvoy, Stephen J. Elliman, Michael J. Kerin, Laura R. Barkley
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Cancer associated fibroblast
Wilms’ tumour 1
Tumour microenvironment
Immunosuppression
Online Access:https://doi.org/10.1186/s12964-025-02292-y
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https://doi.org/10.1186/s12964-025-02292-y

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