Single-cell RNA sequencing reveals the contribution of smooth muscle cells and endothelial cells to fibrosis in human atrial tissue with atrial fibrillation

Single-cell RNA sequencing reveals the contribution of smooth muscle cells and endothelial cells to fibrosis in human atrial tissue with atrial fibrillation

Abstract Aims Atrial fibrillation (AF) has high mortality and morbidity rates. However, the intracellular molecular complexity of the atrial tissue of patients with AF has not been adequately assessed. Methods and results We investigated the cellular heterogeneity of human atrial tissue and changes...

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Bibliographic Details
Main Authors: Na An, Fan Yang, Guoxia Zhang, Yuchen Jiang, Haoqi Liu, Yonghong Gao, Yingjian Li, Peifeng Ji, Hongcai Shang, Yanwei Xing
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Atrial fibrillation
Cardiovascular disease
Single-cell sequencing
Genetics
Genome-wide association study
Online Access:https://doi.org/10.1186/s10020-024-00999-1
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https://doi.org/10.1186/s10020-024-00999-1

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