PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration

PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration

Abstract Intervertebral Disc degeneration (IDD) is one of the leading causes of disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays an essential role in regulating the activation of nuclear factor E2-related factor 2 (Nrf2), while Nrf2 regulates ferroptosis. Howeve...

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Bibliographic Details
Main Authors: Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Intervertebral disc degeneration disease
Phosphodiesterase 4B
Nucleus pulposus
Ferroptosis
Nrf2
Online Access:https://doi.org/10.1038/s41598-025-87639-8
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https://doi.org/10.1038/s41598-025-87639-8

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