Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01

Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01

Abstract Antibodies induced by the malaria vaccine RTS,S/AS01 neutralize infectivity of transgenic sporozoites expressing Plasmodium falciparum CSP (PfCSP). These antibodies recognize the junctional, minor repeats, central repeats, and C-term regions of this antigen. The epitope specificity of antib...

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Main Authors: Yevel Flores-Garcia, Berenice Salgado-Jimenez, Minah Park, Shamika Mathis-Torres, Emily Locke, Randall S. MacGill, Re’em Moskovitz, Ian A. Wilson, Fidel Zavala
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01162-5
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https://doi.org/10.1038/s41541-025-01162-5

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