Evaluation of [<sup>125</sup>I]α-Bungarotoxin Binding to α7 Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Alzheimer’s Disease Brain

Evaluation of [<sup>125</sup>I]α-Bungarotoxin Binding to α7 Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Alzheimer’s Disease Brain

<b>Background/Objectives:</b> Alzheimer’s disease (AD) severely hinders cognitive function in the hippocampus (HP) and subiculum (SUB), impacting the expression of nicotinic acetylcholine receptors (nAChRs) such as the α7-subtype. To investigate α7 nAChRs as a potential PET imaging bioma...

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Bibliographic Details
Main Authors: Allyson Ngo, Fariha Karim, Oshini V. Keerthisinghe, Tram B. Danh, Christopher Liang, Jogeshwar Mukherjee
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Receptors
Subjects:
[<sup>125</sup>I]α-Bungarotoxin
α7 nicotinic acetylcholine receptors
human Aβ plaques
human tau tangles
hippocampus
Alzheimer’s disease
Online Access:https://www.mdpi.com/2813-2564/4/1/7
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