Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report

Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report

ABSTRACT Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long‐standing idiopathic pericarditis remains unreported. We present a 46‐year‐old woman with a decade‐long history of recurrent idiopathic pericarditis who developed multiple pericardial nodules, medi...

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Main Authors: Beatriz Grau Mirete, Paula Rodriguez Paya, Mariano Martinez Marin, Asia Ferrández Arias, Miguel Borregón Rivilla, Antonio David Lazaro Sanchez, Pedro Morillas Blasco, Alvaro Rodriguez‐Lescure, Javier David Benítez Fuentes
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Respirology Case Reports
Subjects:
case report
dual immunotherapy
idiopathic pericarditis
immune checkpoint
pericardial mesothelioma
Online Access:https://doi.org/10.1002/rcr2.70190
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Summary:ABSTRACT Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long‐standing idiopathic pericarditis remains unreported. We present a 46‐year‐old woman with a decade‐long history of recurrent idiopathic pericarditis who developed multiple pericardial nodules, mediastinal lymphadenopathy, and metastatic liver and bone lesions. A core needle biopsy confirmed biphasic MPeM. Due to her pericardial condition, she initially received platinum‐based chemotherapy instead of immunotherapy, but the disease progressed. She then underwent dual immune checkpoint inhibition (ICI) and achieved a significant clinical and radiological response. This case raises the possibility of chronic inflammation contributing to pericardial malignancy and underscores the potential role of dual ICI in this rare and challenging disease.
ISSN:2051-3380

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