The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease
Cardiovascular diseases (CVDs), which are associated with high morbidity and mortality worldwide, include atherosclerosis (AS), hypertension, heart failure (HF), atrial fibrillation, and myocardial fibrosis. CVDs are influenced by the diversity, distribution, and metabolites of intestinal microflora...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2021/3364418 |
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| _version_ | 1832566270630821888 |
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| author | Qiuyu Yan Wenhui Zhai Chenghao Yang Zihao Li Longfei Mao Mingyi Zhao Xiushan Wu |
| author_facet | Qiuyu Yan Wenhui Zhai Chenghao Yang Zihao Li Longfei Mao Mingyi Zhao Xiushan Wu |
| author_sort | Qiuyu Yan |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs), which are associated with high morbidity and mortality worldwide, include atherosclerosis (AS), hypertension, heart failure (HF), atrial fibrillation, and myocardial fibrosis. CVDs are influenced by the diversity, distribution, and metabolites of intestinal microflora, and their risk can be reduced through physical activity (PA) such as regular exercise. PA benefits the metabolic changes that occur in the gut microbiota (GM). The major metabolites of the GM influence pathogenesis of CVDs through various pathways. However, the relationship between PA and GM is less well understood. In this review, we discuss the impacts of different types of PA on intestinal microflora including the diversity, distribution, metabolites, and intestinal barrier function including intestinal permeability, with a focus on the mechanisms by which PA affects GM. We also discuss how GM influences CVDs. Finally, we summarize current research and knowledge on the effects of PA on CVD via regulation of the GM and intestinal function. More understanding of relevant relationship between PA and GM may provide hope for the prevention or treatment of CVDs. Furthermore, a better understanding of regulation of the GM and intestinal function may lead to novel diagnostic and therapeutic strategies, improving the clinical care of CVD patients. |
| format | Article |
| id | doaj-art-3d2b00c9656d4f6fa531747ce19af5bb |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-3d2b00c9656d4f6fa531747ce19af5bb2025-02-03T01:04:33ZengWileyCardiovascular Therapeutics1755-59141755-59222021-01-01202110.1155/2021/33644183364418The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular DiseaseQiuyu Yan0Wenhui Zhai1Chenghao Yang2Zihao Li3Longfei Mao4Mingyi Zhao5Xiushan Wu6Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Pediatric, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaBioinformatics Center, College of Biology, Hunan University, Changsha, 410082 Hunan, ChinaBioinformatics Center, College of Biology, Hunan University, Changsha, 410082 Hunan, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaCardiovascular diseases (CVDs), which are associated with high morbidity and mortality worldwide, include atherosclerosis (AS), hypertension, heart failure (HF), atrial fibrillation, and myocardial fibrosis. CVDs are influenced by the diversity, distribution, and metabolites of intestinal microflora, and their risk can be reduced through physical activity (PA) such as regular exercise. PA benefits the metabolic changes that occur in the gut microbiota (GM). The major metabolites of the GM influence pathogenesis of CVDs through various pathways. However, the relationship between PA and GM is less well understood. In this review, we discuss the impacts of different types of PA on intestinal microflora including the diversity, distribution, metabolites, and intestinal barrier function including intestinal permeability, with a focus on the mechanisms by which PA affects GM. We also discuss how GM influences CVDs. Finally, we summarize current research and knowledge on the effects of PA on CVD via regulation of the GM and intestinal function. More understanding of relevant relationship between PA and GM may provide hope for the prevention or treatment of CVDs. Furthermore, a better understanding of regulation of the GM and intestinal function may lead to novel diagnostic and therapeutic strategies, improving the clinical care of CVD patients.http://dx.doi.org/10.1155/2021/3364418 |
| spellingShingle | Qiuyu Yan Wenhui Zhai Chenghao Yang Zihao Li Longfei Mao Mingyi Zhao Xiushan Wu The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease Cardiovascular Therapeutics |
| title | The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease |
| title_full | The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease |
| title_fullStr | The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease |
| title_full_unstemmed | The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease |
| title_short | The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease |
| title_sort | relationship among physical activity intestinal flora and cardiovascular disease |
| url | http://dx.doi.org/10.1155/2021/3364418 |
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