Reduced glomerular and elevated tubulointerstitial transglutaminase pathway and its inhibition in a rat model of renal warm ischemia: implications for feline chronic kidney disease
IntroductionFeline CKD is associated with an increase in the pro-fibrotic enzyme, transglutaminase 2 (TG2), in the kidney tubulointerstitium. Hypoxia is pivotal factor for the development of CKD, irrespective of its origin. In cats, tubulointerstitial sclerosis develops without significant glomerula...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1520917/full |
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