The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications
Proof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new i...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600801745 |
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| author | André J. Nahmias Susanne Beckman Nahmias Dan Danielsson |
| author_facet | André J. Nahmias Susanne Beckman Nahmias Dan Danielsson |
| author_sort | André J. Nahmias |
| collection | DOAJ |
| description | Proof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood–nervous system barriers to cause NMD's, clinically manifest years later. |
| format | Article |
| id | doaj-art-3cf1a632c80f4436aeea3cd6796d3e99 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3cf1a632c80f4436aeea3cd6796d3e992025-02-03T06:07:56ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01132-416718310.1080/17402520600801745The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine ImplicationsAndré J. Nahmias0Susanne Beckman Nahmias1Dan Danielsson2Pediatric Infectious Diseases, Epidemiology and Immunology Division, Department of Pediatrics and School of Public Health (emeritus), Emory University, Atlanta 30322, GA, USAGeorgia Parents for Responsible Health Education, PO Box 15006, Atlanta 30333, USADepartment of Clinical Microbiology, Örebro University Hospital, Örebro S-701 85, SwedenProof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood–nervous system barriers to cause NMD's, clinically manifest years later.http://dx.doi.org/10.1080/17402520600801745 |
| spellingShingle | André J. Nahmias Susanne Beckman Nahmias Dan Danielsson The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications Clinical and Developmental Immunology |
| title | The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications |
| title_full | The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications |
| title_fullStr | The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications |
| title_full_unstemmed | The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications |
| title_short | The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications |
| title_sort | possible role of transplacentally acquired antibodies to infectious agents with molecular mimicry to nervous system sialic acid epitopes as causes of neuromental disorders prevention and vaccine implications |
| url | http://dx.doi.org/10.1080/17402520600801745 |
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