Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus
The thermal reactions of amino acids have been investigated for pure organic synthesis, materials preparation in industry, and prebiotic chemistry. N-t-Butyloxycarbonyl aspartic acid (Boc-Asp) releases 2-butene and carbon dioxide upon heating without solvents. The resulting mixture of the free molte...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2017/8364710 |
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| author | Toratane Munegumi Takafumi Yamada |
| author_facet | Toratane Munegumi Takafumi Yamada |
| author_sort | Toratane Munegumi |
| collection | DOAJ |
| description | The thermal reactions of amino acids have been investigated for pure organic synthesis, materials preparation in industry, and prebiotic chemistry. N-t-Butyloxycarbonyl aspartic acid (Boc-Asp) releases 2-butene and carbon dioxide upon heating without solvents. The resulting mixture of the free molten aspartic acid was dehydrated to give peptide bonds. This study describes the thermal reactions of N-t-butyloxycarbonyl peptides (Boc-Gly-L-Asp, Boc-L-Ala-L-Asp, Boc-L-Val-L-Asp, and Boc-Gly-Gly-L-Asp) having an aspartic residue at the carboxyl terminus. The peptides were deprotected upon heating at a constant temperature between 110 and 170°C for 1 to 24 h to afford polypeptides in which the average molecular weight reached 7800. |
| format | Article |
| id | doaj-art-3cedb37a17ef457ab0e69d9669475a32 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-3cedb37a17ef457ab0e69d9669475a322025-02-03T05:57:42ZengWileyInternational Journal of Polymer Science1687-94221687-94302017-01-01201710.1155/2017/83647108364710Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-TerminusToratane Munegumi0Takafumi Yamada1Department of Science Education, Naruto University of Education, Naruto, Tokushima 772-8502, JapanDepartment of Chemistry, University of Tsukuba, Tsukuba, Ibaraki 305-857, JapanThe thermal reactions of amino acids have been investigated for pure organic synthesis, materials preparation in industry, and prebiotic chemistry. N-t-Butyloxycarbonyl aspartic acid (Boc-Asp) releases 2-butene and carbon dioxide upon heating without solvents. The resulting mixture of the free molten aspartic acid was dehydrated to give peptide bonds. This study describes the thermal reactions of N-t-butyloxycarbonyl peptides (Boc-Gly-L-Asp, Boc-L-Ala-L-Asp, Boc-L-Val-L-Asp, and Boc-Gly-Gly-L-Asp) having an aspartic residue at the carboxyl terminus. The peptides were deprotected upon heating at a constant temperature between 110 and 170°C for 1 to 24 h to afford polypeptides in which the average molecular weight reached 7800.http://dx.doi.org/10.1155/2017/8364710 |
| spellingShingle | Toratane Munegumi Takafumi Yamada Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus International Journal of Polymer Science |
| title | Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus |
| title_full | Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus |
| title_fullStr | Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus |
| title_full_unstemmed | Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus |
| title_short | Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus |
| title_sort | thermal synthesis of polypeptides from n butyloxycarbonyl oligopeptides containing aspartyl residue at c terminus |
| url | http://dx.doi.org/10.1155/2017/8364710 |
| work_keys_str_mv | AT toratanemunegumi thermalsynthesisofpolypeptidesfromnbutyloxycarbonyloligopeptidescontainingaspartylresidueatcterminus AT takafumiyamada thermalsynthesisofpolypeptidesfromnbutyloxycarbonyloligopeptidescontainingaspartylresidueatcterminus |