Selection and characterization of DNA aptamers targeting the surface Borrelia protein CspZ with high-throughput cross-over SELEX

Selection and characterization of DNA aptamers targeting the surface Borrelia protein CspZ with high-throughput cross-over SELEX

Abstract Lyme borreliosis (LB) is the most prevalent tick-borne illness, with an estimated 700 000 cases annually in the United States and Europe. The LB diagnosis based on a two-tiered serology remains controversial due to its indirect nature and low sensitivity during the early stage of the diseas...

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Main Authors: Mickaël Guérin, Marylène Vandevenne, André Matagne, Willy Aucher, Julien Verdon, Emmeline Paoli, Jules Ducrotoy, Stéphane Octave, Bérangère Avalle, Irene Maffucci, Séverine Padiolleau-Lefèvre
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08034-7
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https://doi.org/10.1038/s42003-025-08034-7

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