Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells

Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells

CD4+ regulatory T cells (TREGS) are critical for immune tolerance and the transcription factor Forkhead Box P3 (FOXP3) plays a crucial role in their differentiation and function. Recently, an alternative promoter has been reported for FOXP3, which is active only in TREGS and could have profound impl...

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Main Authors: Marcos Cases, Niclas Ritter, Hector Rincon-Arevalo, Sandy Kroh, Aysegül Adam, Marieluise Kirchner, Hanieh Moradian, Manfred Gossen, Maria Dzamukova, Artür Manukyan, Markus Landthaler, Christopher Kressler, Anja E. Hauser, Daniel P. Depledge, Julia K. Polansky, Hyun-Dong Chang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:RNA Biology
Subjects:
FOXP3
TREG
alternative promoter
transcript isoform
transcriptional interference
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2025.2502719
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https://www.tandfonline.com/doi/10.1080/15476286.2025.2502719

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