Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study
Abstract BackgroundPatients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life () and clinical outcome to immunotherapy...
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JMIR Publications
2025-01-01
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| Series: | JMIR Cancer |
| Online Access: | https://cancer.jmir.org/2025/1/e58938 |
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| author | Itske Fraterman Lucia Sacchi Henk Mallo Valentina Tibollo Savannah Lucia Catherina Glaser Stephanie Medlock Ronald Cornet Matteo Gabetta Vitali Hisko Vadzim Khadakou Ella Barkan Laura Del Campo David Glasspool Alexandra Kogan Giordano Lanzola Roy Leizer Manuel Ottaviano Mor Peleg Konrad Śniatała Aneta Lisowska Szymon Wilk Enea Parimbelli Silvana Quaglini Mimma Rizzo Laura Deborah Locati Annelies Boekhout Lonneke V van de Poll-Franse Sofie Wilgenhof |
| author_facet | Itske Fraterman Lucia Sacchi Henk Mallo Valentina Tibollo Savannah Lucia Catherina Glaser Stephanie Medlock Ronald Cornet Matteo Gabetta Vitali Hisko Vadzim Khadakou Ella Barkan Laura Del Campo David Glasspool Alexandra Kogan Giordano Lanzola Roy Leizer Manuel Ottaviano Mor Peleg Konrad Śniatała Aneta Lisowska Szymon Wilk Enea Parimbelli Silvana Quaglini Mimma Rizzo Laura Deborah Locati Annelies Boekhout Lonneke V van de Poll-Franse Sofie Wilgenhof |
| author_sort | Itske Fraterman |
| collection | DOAJ |
| description |
Abstract
BackgroundPatients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life () and clinical outcome to immunotherapy. eHealth tools can aid patients with cancer in addressing issues, such as adverse events and psychosocial well-being, from various perspectives.
ObjectiveThis study aimed to explore the effect of the Cancer Patients Better Life Experience (CAPABLE) system, accessed through a mobile app, on HRQoL compared with a matched historical control group receiving standard care. CAPABLE is an extensively tested eHealth app, including educational material, remote symptom monitoring, and well-being interventions.
MethodsThis prospective pilot study compared an exploratory cohort that received the CAPABLE smartphone app and a multisensory smartwatch for 6 months (intervention) to a 2:1 individually matched historical prospective control group. HRQoL data were measured with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 at baseline (T0), 3 months (T1), and 6 months (T2) after start of treatment. Mixed effects linear regression models were used to compare HRQoL between the 2 groups over time.
ResultsFrom the 59 eligible patients for the CAPABLE intervention, 31 (53%) signed informed consent to participate. Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. When correcting for sex, age, disease stage, and baseline scores, an adjusted difference in fatigue of −5.09 (95% CI −15.20 to 5.02, P=P
ConclusionsThe intervention showed a limited effect on HRQoL, although there was a small improvement in fatigue at 3 months, as well as information satisfaction. When aiming at personalized patient and survivorship care, further optimization and prospective investigation of eHealth tools is warranted. |
| format | Article |
| id | doaj-art-3c8c0513ee384c038a3a7273a4e3e04b |
| institution | Kabale University |
| issn | 2369-1999 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Cancer |
| spelling | doaj-art-3c8c0513ee384c038a3a7273a4e3e04b2025-02-06T15:03:53ZengJMIR PublicationsJMIR Cancer2369-19992025-01-0111e58938e5893810.2196/58938Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot StudyItske Fratermanhttp://orcid.org/0000-0001-7974-8422Lucia Sacchihttp://orcid.org/0000-0002-1390-9825Henk Mallohttp://orcid.org/0000-0001-6555-4942Valentina Tibollohttp://orcid.org/0000-0003-2687-3822Savannah Lucia Catherina Glaserhttp://orcid.org/0000-0003-0103-079XStephanie Medlockhttp://orcid.org/0000-0002-2679-8095Ronald Cornethttp://orcid.org/0000-0002-1704-5980Matteo Gabettahttp://orcid.org/0000-0001-9140-768XVitali Hiskohttp://orcid.org/0009-0009-3886-7228Vadzim Khadakouhttp://orcid.org/0009-0007-3350-6269Ella Barkanhttp://orcid.org/0000-0001-6521-3873Laura Del Campohttp://orcid.org/0009-0001-6481-8341David Glasspoolhttp://orcid.org/0000-0001-7688-8251Alexandra Koganhttp://orcid.org/0000-0002-5926-1606Giordano Lanzolahttp://orcid.org/0000-0003-3190-5104Roy Leizerhttp://orcid.org/0009-0000-3149-4427Manuel Ottavianohttp://orcid.org/0000-0003-0002-4988Mor Peleghttp://orcid.org/0000-0002-5612-768XKonrad Śniatałahttp://orcid.org/0000-0003-0746-5399Aneta Lisowskahttp://orcid.org/0000-0002-4489-5956Szymon Wilkhttp://orcid.org/0000-0002-7807-454XEnea Parimbellihttp://orcid.org/0000-0003-0679-828XSilvana Quaglinihttp://orcid.org/0000-0002-4288-2561Mimma Rizzohttp://orcid.org/0000-0001-7743-741XLaura Deborah Locatihttp://orcid.org/0000-0003-3315-2580Annelies Boekhouthttp://orcid.org/0000-0003-3637-0655Lonneke V van de Poll-Fransehttp://orcid.org/0000-0003-0413-6872Sofie Wilgenhofhttp://orcid.org/0000-0002-3309-4555 Abstract BackgroundPatients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life () and clinical outcome to immunotherapy. eHealth tools can aid patients with cancer in addressing issues, such as adverse events and psychosocial well-being, from various perspectives. ObjectiveThis study aimed to explore the effect of the Cancer Patients Better Life Experience (CAPABLE) system, accessed through a mobile app, on HRQoL compared with a matched historical control group receiving standard care. CAPABLE is an extensively tested eHealth app, including educational material, remote symptom monitoring, and well-being interventions. MethodsThis prospective pilot study compared an exploratory cohort that received the CAPABLE smartphone app and a multisensory smartwatch for 6 months (intervention) to a 2:1 individually matched historical prospective control group. HRQoL data were measured with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 at baseline (T0), 3 months (T1), and 6 months (T2) after start of treatment. Mixed effects linear regression models were used to compare HRQoL between the 2 groups over time. ResultsFrom the 59 eligible patients for the CAPABLE intervention, 31 (53%) signed informed consent to participate. Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. When correcting for sex, age, disease stage, and baseline scores, an adjusted difference in fatigue of −5.09 (95% CI −15.20 to 5.02, P=P ConclusionsThe intervention showed a limited effect on HRQoL, although there was a small improvement in fatigue at 3 months, as well as information satisfaction. When aiming at personalized patient and survivorship care, further optimization and prospective investigation of eHealth tools is warranted.https://cancer.jmir.org/2025/1/e58938 |
| spellingShingle | Itske Fraterman Lucia Sacchi Henk Mallo Valentina Tibollo Savannah Lucia Catherina Glaser Stephanie Medlock Ronald Cornet Matteo Gabetta Vitali Hisko Vadzim Khadakou Ella Barkan Laura Del Campo David Glasspool Alexandra Kogan Giordano Lanzola Roy Leizer Manuel Ottaviano Mor Peleg Konrad Śniatała Aneta Lisowska Szymon Wilk Enea Parimbelli Silvana Quaglini Mimma Rizzo Laura Deborah Locati Annelies Boekhout Lonneke V van de Poll-Franse Sofie Wilgenhof Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study JMIR Cancer |
| title | Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study |
| title_full | Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study |
| title_fullStr | Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study |
| title_full_unstemmed | Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study |
| title_short | Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective Pilot Study |
| title_sort | exploring the impact of the multimodal capable ehealth intervention on health related quality of life in patients with melanoma undergoing immune checkpoint inhibition prospective pilot study |
| url | https://cancer.jmir.org/2025/1/e58938 |
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