Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study
ABSTRACT Background and Aims A catheter‐related bloodstream infection (CRBSI) is a life‐threatening complication of hemodialysis. It is responsible for significant morbidity and mortality and a costly long hospital stay. Despite its burden, little is known about the factors associated with it and th...
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Wiley
2025-01-01
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| Online Access: | https://doi.org/10.1002/hsr2.70338 |
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| author | Andrea R. Costantine Sarah J. Urasa Abid M. Sadiq Elichilia R. Shao Furaha S. Lyamuya Elieishiupendo M. Niccodem Eugénie M. Kamabu Venance P. Maro Elifuraha W. Mkwizu Nyasatu G. Chamba Francis F. Furia Tumaini E. Mirai Eliada B. Nziku Doreen T. Eliah Ibrahim Ali Ibrahim Muhina Faryal M. Raza Modesta P. Mitao Kajiru G. Kilonzo |
| author_facet | Andrea R. Costantine Sarah J. Urasa Abid M. Sadiq Elichilia R. Shao Furaha S. Lyamuya Elieishiupendo M. Niccodem Eugénie M. Kamabu Venance P. Maro Elifuraha W. Mkwizu Nyasatu G. Chamba Francis F. Furia Tumaini E. Mirai Eliada B. Nziku Doreen T. Eliah Ibrahim Ali Ibrahim Muhina Faryal M. Raza Modesta P. Mitao Kajiru G. Kilonzo |
| author_sort | Andrea R. Costantine |
| collection | DOAJ |
| description | ABSTRACT Background and Aims A catheter‐related bloodstream infection (CRBSI) is a life‐threatening complication of hemodialysis. It is responsible for significant morbidity and mortality and a costly long hospital stay. Despite its burden, little is known about the factors associated with it and the antibiogram of its responsible causative bacteria. This study aimed to evaluate the determinants of hemodialysis CRBSI and the appropriate antibiogram for the isolated bacterial pathogens among patients attending the KCMC hemodialysis unit. Methods A hospital‐based retrospective analytical cross‐sectional study involved adult patients with CKD or AKI undergoing hemodialysis at KCMC with tunneled or non‐tunneled central venous catheters who attended from January 1, 2021 to December 31, 2022. Data were collected from the hospital's electronic medical record system. Statistical analysis was performed using SPSS version 27. Multivariate logistic regression was used to determine the factors associated with CRBSI. A p‐value of < 0.05 was considered statistically significant. Results A total of 286 patients were analyzed. The patients were predominantly males (70.6%), and more than half were above 55 years old (56%), with a mean age of 58 (SD ± 14.8) years. 56.6% developed CRBSI and were predominantly gram‐positive (69.7%). Major associated factors were hypoalbuminemia of < 35 g/dL, diabetes mellitus, anemia of hemoglobin < 10 g/dL, and having a femoral central venous catheter. For gram‐positive bacteria, the most efficient antibiotic was vancomycin, with an overall average efficacy of 99% for all isolates. For gram‐negative bacteria, the most efficient antibiotic was meropenem, with an overall average efficacy of 82.1% for all isolates. Conclusion Over 50% of patients developed CRBSI and gram‐positive bacteria were the major causative bacteria. Associated factors were multifactorial and preventive care would be ideal to reduce the number of CRBSI based on these findings. |
| format | Article |
| id | doaj-art-3c374ae634bf4fc885fcfc7d7b18d05e |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-3c374ae634bf4fc885fcfc7d7b18d05e2025-01-29T03:42:40ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70338Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective StudyAndrea R. Costantine0Sarah J. Urasa1Abid M. Sadiq2Elichilia R. Shao3Furaha S. Lyamuya4Elieishiupendo M. Niccodem5Eugénie M. Kamabu6Venance P. Maro7Elifuraha W. Mkwizu8Nyasatu G. Chamba9Francis F. Furia10Tumaini E. Mirai11Eliada B. Nziku12Doreen T. Eliah13Ibrahim Ali Ibrahim Muhina14Faryal M. Raza15Modesta P. Mitao16Kajiru G. Kilonzo17Department of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical Centre Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Muhimbili University of Health and Allied Sciences Dar es Salaam TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaDepartment of Clinical Research Kilimanjaro Clinical Research Institute Moshi TanzaniaDepartment of Internal Medicine Kilimanjaro Christian Medical University College Moshi TanzaniaABSTRACT Background and Aims A catheter‐related bloodstream infection (CRBSI) is a life‐threatening complication of hemodialysis. It is responsible for significant morbidity and mortality and a costly long hospital stay. Despite its burden, little is known about the factors associated with it and the antibiogram of its responsible causative bacteria. This study aimed to evaluate the determinants of hemodialysis CRBSI and the appropriate antibiogram for the isolated bacterial pathogens among patients attending the KCMC hemodialysis unit. Methods A hospital‐based retrospective analytical cross‐sectional study involved adult patients with CKD or AKI undergoing hemodialysis at KCMC with tunneled or non‐tunneled central venous catheters who attended from January 1, 2021 to December 31, 2022. Data were collected from the hospital's electronic medical record system. Statistical analysis was performed using SPSS version 27. Multivariate logistic regression was used to determine the factors associated with CRBSI. A p‐value of < 0.05 was considered statistically significant. Results A total of 286 patients were analyzed. The patients were predominantly males (70.6%), and more than half were above 55 years old (56%), with a mean age of 58 (SD ± 14.8) years. 56.6% developed CRBSI and were predominantly gram‐positive (69.7%). Major associated factors were hypoalbuminemia of < 35 g/dL, diabetes mellitus, anemia of hemoglobin < 10 g/dL, and having a femoral central venous catheter. For gram‐positive bacteria, the most efficient antibiotic was vancomycin, with an overall average efficacy of 99% for all isolates. For gram‐negative bacteria, the most efficient antibiotic was meropenem, with an overall average efficacy of 82.1% for all isolates. Conclusion Over 50% of patients developed CRBSI and gram‐positive bacteria were the major causative bacteria. Associated factors were multifactorial and preventive care would be ideal to reduce the number of CRBSI based on these findings.https://doi.org/10.1002/hsr2.70338antibiogramcatheter related bloodstream infectionshemodialysis |
| spellingShingle | Andrea R. Costantine Sarah J. Urasa Abid M. Sadiq Elichilia R. Shao Furaha S. Lyamuya Elieishiupendo M. Niccodem Eugénie M. Kamabu Venance P. Maro Elifuraha W. Mkwizu Nyasatu G. Chamba Francis F. Furia Tumaini E. Mirai Eliada B. Nziku Doreen T. Eliah Ibrahim Ali Ibrahim Muhina Faryal M. Raza Modesta P. Mitao Kajiru G. Kilonzo Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study Health Science Reports antibiogram catheter related bloodstream infections hemodialysis |
| title | Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study |
| title_full | Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study |
| title_fullStr | Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study |
| title_full_unstemmed | Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study |
| title_short | Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study |
| title_sort | catheter related bloodstream infections among hemodialysis patients in northern tanzania insights from a single centre retrospective study |
| topic | antibiogram catheter related bloodstream infections hemodialysis |
| url | https://doi.org/10.1002/hsr2.70338 |
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