Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening
Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step gr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/207573 |
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| author | Langis Michaud |
| author_facet | Langis Michaud |
| author_sort | Langis Michaud |
| collection | DOAJ |
| description | Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is proposed to classify this new entity. Results. Group A (Fabry) comprised 16 males and 22 females, aged 40 (±14) years on average. Group B (control) comprised 7 males and 8 females, aged 37 (±12) Vessels tortuosity was identified on the external superior lid in 36 of the Fabry patients (94.7%), while none of the subjects in group B showed similar vessels tortuosity. In addition, microaneurysms (MAs) were found in 10/38 group A subjects while none in group B presented a similar finding. The differences are highly significant. Conclusion. This paper proposes that blood vessels tortuosity on the upper eyelid be recognized as a new clinical entity for inclusion among the classic ocular manifestations of Fabry’s disease. Without evidence of any negative impact, it should be considered a benign sign contributing to evidence of suspected Fabry disease. |
| format | Article |
| id | doaj-art-3c0013e16a8c491e8d084db1a8362716 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3c0013e16a8c491e8d084db1a83627162025-02-03T05:53:48ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/207573207573Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient ScreeningLangis Michaud0École d’Optométrie de l’Université de Montréal, 3744 Jean Brillant, Suite 190-70, Montreal, QC, H3T 1P1, CanadaPurpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is proposed to classify this new entity. Results. Group A (Fabry) comprised 16 males and 22 females, aged 40 (±14) years on average. Group B (control) comprised 7 males and 8 females, aged 37 (±12) Vessels tortuosity was identified on the external superior lid in 36 of the Fabry patients (94.7%), while none of the subjects in group B showed similar vessels tortuosity. In addition, microaneurysms (MAs) were found in 10/38 group A subjects while none in group B presented a similar finding. The differences are highly significant. Conclusion. This paper proposes that blood vessels tortuosity on the upper eyelid be recognized as a new clinical entity for inclusion among the classic ocular manifestations of Fabry’s disease. Without evidence of any negative impact, it should be considered a benign sign contributing to evidence of suspected Fabry disease.http://dx.doi.org/10.1155/2013/207573 |
| spellingShingle | Langis Michaud Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening Journal of Ophthalmology |
| title | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening |
| title_full | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening |
| title_fullStr | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening |
| title_full_unstemmed | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening |
| title_short | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening |
| title_sort | vascular tortuosities of the upper eyelid a new clinical finding in fabry patient screening |
| url | http://dx.doi.org/10.1155/2013/207573 |
| work_keys_str_mv | AT langismichaud vasculartortuositiesoftheuppereyelidanewclinicalfindinginfabrypatientscreening |