Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice

Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice

Abstract Growth differentiation factor-15 (GDF15) is a biomarker of multiple disease states and circulating GDF15 levels are increased during aging in both pre-clinical animal models and human studies. Accordingly, multiple stressors have been identified, including mitochondrial dysfunction, that le...

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Main Authors: J. Chen, J. Kastroll, F. M. Bello, M. M. Pangburn, A. Murali, P. M. Smith, K. Rychcik, K. E. Loughridge, A. M. Vandevender, N. Dedousis, I. J. Sipula, J. K. Alder, M. J. Jurczak
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Integrated stress response
Aging
Respirometry
Insulin resistance
Energy expenditure
Online Access:https://doi.org/10.1038/s41598-025-92572-x
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https://doi.org/10.1038/s41598-025-92572-x

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