The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma

The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma

The efficacy of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) remains limited. The tumor microenvironment (TME), characterized by the accumulation of suppressive myeloid cells including neutrophils, attributes to immunotherapy resistance in PDAC. IgA monoclonal antibodies (mAbs) can activ...

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Bibliographic Details
Main Authors: Léon Raymakers, Elsemieke M. Passchier, Meggy E. L. Verdonschot, Mitchell Evers, Chilam Chan, Karel C. Kuijpers, G. Mihaela Raicu, I. Quintus Molenaar, Hjalmar C. van Santvoort, Karin Strijbis, Martijn P. W. Intven, Lois A. Daamen, Jeanette H. W. Leusen, Patricia A. Olofsen
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
IgA
monoclonal antibodies
mAbs
neutrophils
polymorphonuclear cells
PMNs
Online Access:https://www.mdpi.com/2073-4409/14/9/632
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