A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

Abstract Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling is hyperactivated in the skin, especially in the epidermis, of both rosacea patients and a mouse model of rosacea‐like skin infla...

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Bibliographic Details
Main Authors: Zhili Deng, Mengting Chen, Yingzi Liu, San Xu, Yuyan Ouyang, Wei Shi, Dan Jian, Ben Wang, Fangfen Liu, Jinmao Li, Qian Shi, Qinqin Peng, Ke Sha, Wenqin Xiao, Tangxiele Liu, Yiya Zhang, Hongbing Zhang, Qian Wang, Lunquan Sun, Hongfu Xie, Ji Li
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:EMBO Molecular Medicine
Subjects:
LL37
mTOR
Rapamycin
rosacea
skin inflammation
Online Access:https://doi.org/10.15252/emmm.202013560
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