Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression

Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), which affects a significant portion of the global population, is linked to high-fat diets (HFD) and characterized by abnormal lipid accumulation and activation of inflammatory pathways in hepatocytes. The precise mechanisms u...

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Main Authors: Rabia Johnson, Samukelisiwe Shabalala, Lawrence Mabasa, Liske Kotzé-Hörstmann, Nonhlakanipho Sangweni, Pritika Ramharack, Jyoti Sharma, Carmen Pheiffer, Afolake Arowolo, Hanél Sadie-Van Gijsen
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
High-fat diet (HFD)
Obesity
Non-alcoholic fatty liver disease (NAFLD)
Inflammation
Metabolic dysfunction
Steatotic fatty liver diseases (MASLD)
Online Access:https://doi.org/10.1038/s41598-025-02001-2
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https://doi.org/10.1038/s41598-025-02001-2

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