A Statistical Approach for Comparative Assessment of the Effect of Smoke Exposure in In Vivo Experiments: A Case Study of an OECD 90-Day Inhalation Study Including 3R4F and 1R6F Reference Cigarettes

A Statistical Approach for Comparative Assessment of the Effect of Smoke Exposure in In Vivo Experiments: A Case Study of an OECD 90-Day Inhalation Study Including 3R4F and 1R6F Reference Cigarettes

In vivo testing is a crucial part of product development. Most in vivo toxicology studies are conducted in a heavily regulated environment, in accordance with sound scientific principles, and in an ethical manner. Statistical methods are an important component of these scientific principles, and man...

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Bibliographic Details
Main Authors: Kondylis Athanasios, Kogel Ulrike, Ho Jenny, Wong EeTsin, Phillips Blaine, Hoeng Julia, Vanscheeuwijck Patrick
Format: Article
Language:English
Published: Sciendo 2025-01-01
Series:Contributions to Tobacco and Nicotine Research
Subjects:
in vivo testing
reference cigarette smoke
statistical equivalence
statistical intervals
Online Access:https://doi.org/10.2478/cttr-2025-0003
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