Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice
Background: Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM), a major component of air pollution, is associated with the development of cardiovascular diseases (CVDs). Cellular senescence and other aging mechanisms are also key factors in the developmen...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4433/16/1/109 |
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| author | Dunia Waked Gabriel Henrique Rodella Guedes Raissa Macedo Paulo Hilário Nascimento Saldiva Mariana Matera Veras Ana Paula Cremasco Takano |
| author_facet | Dunia Waked Gabriel Henrique Rodella Guedes Raissa Macedo Paulo Hilário Nascimento Saldiva Mariana Matera Veras Ana Paula Cremasco Takano |
| author_sort | Dunia Waked |
| collection | DOAJ |
| description | Background: Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM), a major component of air pollution, is associated with the development of cardiovascular diseases (CVDs). Cellular senescence and other aging mechanisms are also key factors in the development and progression of CVD. This study aims to investigate age-related susceptibility to cardiac remodeling and senescence due to PM exposure. Methods: Young and old male C57BL/6 mice were exposed to filtered or polluted air for six months using an ambient particle concentrator. Cardiac hypertrophy, fibrosis, and markers of cellular senescence (p53, p21, p-H2AX, and lipofuscin) in the myocardium were evaluated in the experimental groups. Results: PM exposure induces signs of cardiac remodeling, including cardiomyocyte enlargement and increased fibrosis, in young mice, along with elevated p53 expression. However, no significant alterations in cardiac structure or senescence markers were observed between aged mice exposed or not to PM. Conclusions: Our study indicates that younger individuals may be more vulnerable to the cardiovascular effects of chronic PM than older individuals exposed later. Further studies are needed to explore detailed mechanisms of this age-dependent response. |
| format | Article |
| id | doaj-art-3b50f2d061a34cdba1c75d2db9ae0012 |
| institution | Kabale University |
| issn | 2073-4433 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Atmosphere |
| spelling | doaj-art-3b50f2d061a34cdba1c75d2db9ae00122025-01-24T13:22:03ZengMDPI AGAtmosphere2073-44332025-01-0116110910.3390/atmos16010109Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged MiceDunia Waked0Gabriel Henrique Rodella Guedes1Raissa Macedo2Paulo Hilário Nascimento Saldiva3Mariana Matera Veras4Ana Paula Cremasco Takano5Laboratory of Environmental and Experimental Pathology, LIM05—Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilDepartment of Anatomy, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo 05508-000, BrazilDepartment of Anatomy, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo 05508-000, BrazilDepartment of Pathology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilLaboratory of Environmental and Experimental Pathology, LIM05—Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilDepartment of Anatomy, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo 05508-000, BrazilBackground: Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM), a major component of air pollution, is associated with the development of cardiovascular diseases (CVDs). Cellular senescence and other aging mechanisms are also key factors in the development and progression of CVD. This study aims to investigate age-related susceptibility to cardiac remodeling and senescence due to PM exposure. Methods: Young and old male C57BL/6 mice were exposed to filtered or polluted air for six months using an ambient particle concentrator. Cardiac hypertrophy, fibrosis, and markers of cellular senescence (p53, p21, p-H2AX, and lipofuscin) in the myocardium were evaluated in the experimental groups. Results: PM exposure induces signs of cardiac remodeling, including cardiomyocyte enlargement and increased fibrosis, in young mice, along with elevated p53 expression. However, no significant alterations in cardiac structure or senescence markers were observed between aged mice exposed or not to PM. Conclusions: Our study indicates that younger individuals may be more vulnerable to the cardiovascular effects of chronic PM than older individuals exposed later. Further studies are needed to explore detailed mechanisms of this age-dependent response.https://www.mdpi.com/2073-4433/16/1/109particulate mattercardiac remodelingsenescencecardiac aging |
| spellingShingle | Dunia Waked Gabriel Henrique Rodella Guedes Raissa Macedo Paulo Hilário Nascimento Saldiva Mariana Matera Veras Ana Paula Cremasco Takano Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice Atmosphere particulate matter cardiac remodeling senescence cardiac aging |
| title | Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice |
| title_full | Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice |
| title_fullStr | Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice |
| title_full_unstemmed | Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice |
| title_short | Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice |
| title_sort | differential susceptibility to particulate matter induced cardiac remodeling and senescence a comparative study in young and aged mice |
| topic | particulate matter cardiac remodeling senescence cardiac aging |
| url | https://www.mdpi.com/2073-4433/16/1/109 |
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