Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor

Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor

Introduction Out-of-hospital cardiac arrest is a public health concern with a high mortality rate. Hypoxic ischaemic brain injury is the primary cause of death in patients admitted to the intensive care unit (ICU) after return of spontaneous circulation (ROSC). Several systemic factors, such as hypo...

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Main Authors: Cédric Bruel, Christophe Guitton, Jean-Pierre Frat, Jeremy Bourenne, Guylaine Labro, Jean-Pierre Quenot, Gwenhaël Colin, Arnaud W Thille, Christophe Guervilly, Kada Klouche, Laurence Dangers, Jean Reignier, Agathe Delbove, Nicholas Sedillot, Jean-Paul Mira, Laurent Argaud, Martin Dres, Jérôme Roustan, Elsa Parot-Schinkel, Pierre Bailly, Pierre Asfar, Jean-Philippe Rigaud, Jean-Claude Lacherade, Grégoire Muller, Guillaume Geri, Jean-Baptiste Lascarrou, Julio Badie, Julien Maizel, Frédéric Martino, Gaetan Plantefeve, Francis Schneider, Alain Cariou, Xavier Wittebole, Denis Doyen, Bruno Francois, Pierre-Francois Dequin, Francois Barbier, Ferhat Meziani, David Schnell, Hamid Merdji, Jonathan Chelly, Olivier Lesieur, Caroline Sejourne, Wulfran Bougouin, Nicolas Pichon, Mehran Monchi, Charlotte Salmon Gandonniere, Saber Davide Barbar, Juliette Audibert, Sophie Jacquier, Julien Lorber, Marine Goudelin, Nicolas Chudeau, Nicolas Brechot, Thomas Klein, Eglantine Rouanet, Patrick Saulnier, Olivier Nigeon, Nicolas De Schryver, Fabien Jarousseau, Marine Paul, Benoît Painvin, Damien Du Cheyron, Antoine Marchalot, Tristan Morichau-Beauchant, Patrick Girardie, W Bougouin, Mathieu Jozwiak, Frédéric Foret, Djillali Annane F-CRIN, Asaël Berger PierreBulpa, Nicolas Barbarot, Nicolas Mongardon CédricDaubin, Asael Berge, Simon Bourcier, Guillaume Geri Jean-BaptisteLascarrou, Jean-Herle Raphalen, Florence Blossier, Fanny Bounes, William Buffières
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/4/e096997.full
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