IGN: Invariable gene set-based normalization for chromatin accessibility profile data analysis
Chromatin accessibility profiles generated using ATAC-seq or DNase-seq carry functional information of the regulatory genome that controls gene expression. Appropriate normalization of ATAC-seq and DNase-seq data is essential for accurate differential analysis when studying chromatin dynamics. Exist...
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Main Authors: | Shengen Shawn Hu, Hai-Hui Xue, Chongzhi Zang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-01-01
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Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037025000170 |
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