IGN: Invariable gene set-based normalization for chromatin accessibility profile data analysis

Chromatin accessibility profiles generated using ATAC-seq or DNase-seq carry functional information of the regulatory genome that controls gene expression. Appropriate normalization of ATAC-seq and DNase-seq data is essential for accurate differential analysis when studying chromatin dynamics. Exist...

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Bibliographic Details
Main Authors: Shengen Shawn Hu, Hai-Hui Xue, Chongzhi Zang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
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Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025000170
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