Evaluating Nanoparticulate Vaccine Formulations for Effective Antigen Presentation and T-Cell Proliferation Using an In Vitro Overlay Assay

Evaluating Nanoparticulate Vaccine Formulations for Effective Antigen Presentation and T-Cell Proliferation Using an In Vitro Overlay Assay

Inducing T lymphocyte (T-cell) activation and proliferation with specificity against a pathogen is crucial in vaccine formulation. Assessing vaccine candidates’ ability to induce T-cell proliferation helps optimize formulation for its safety, immunogenicity, and efficacy. Our in-house vaccine candid...

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Bibliographic Details
Main Authors: Dedeepya Pasupuleti, Priyal Bagwe, Amarae Ferguson, Mohammad N. Uddin, Martin J. D’Souza, Susu M. Zughaier
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Vaccines
Subjects:
T-cell proliferation
overlay assay
cell-to-cell contact
antigen-presenting cell
dendritic cell
antigen presentation
Online Access:https://www.mdpi.com/2076-393X/12/9/1049
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