Inhibition of class IIa HDACs reduces mutant HTT aggregation by affecting RNA stability

Inhibition of class IIa HDACs reduces mutant HTT aggregation by affecting RNA stability

IntroductionHuntington’s disease (HD) is a fatal inherited neurological disorder for which there are no curative treatments available. Patients suffer from progressive impairment in cognitive and motor functions. Transcriptional dysregulation is a major molecular disease mechanism of HD. Transcripti...

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Main Authors: Annika Reisbitzer, Cecilia Hollitzer, Adriana Geraci, Jessye Schaefer, Maximilian Burghaus, Jonas Bruns, Joachim Urban, Thomas Kurz, Sybille Krauß
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Huntington’s disease
class IIa histone deacetylases
RNA stability
RNA-binding protein
polyglutamine protein
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1579194/full
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