Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS
Abstract Atherosclerosis is a primary cause of cardiovascular disease, straining healthcare systems. Dendrobium officinale, a widely used food-medicine homology, has demonstrated anti-atherosclerotic (anti-AS) properties, with other species listed in pharmacopoeias exhibiting similar effects. Howeve...
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Nature Portfolio
2025-01-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00371-5 |
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| author | Yu Zhang Xi Chen Oushan Tang Keyun Cheng Lijun Ge Weibo Lu Jing Zheng Yeshun Wu Si-wei Wang Xi-xi Zeng Jing Xue Yiwei Cui Liting Ji Qing Shen |
| author_facet | Yu Zhang Xi Chen Oushan Tang Keyun Cheng Lijun Ge Weibo Lu Jing Zheng Yeshun Wu Si-wei Wang Xi-xi Zeng Jing Xue Yiwei Cui Liting Ji Qing Shen |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Abstract Atherosclerosis is a primary cause of cardiovascular disease, straining healthcare systems. Dendrobium officinale, a widely used food-medicine homology, has demonstrated anti-atherosclerotic (anti-AS) properties, with other species listed in pharmacopoeias exhibiting similar effects. However, their efficacy varies, and the impact of interspecies variations on compounds and mechanisms in Dendrobium’s anti-AS effects remains unclear. This study aimed to explore the anti-AS compounds and mechanisms across various Dendrobium species. The chemical composition of D. fimbriatum, D. officinale, D. devonianum, D. gratiosissimum, and D. catenatum was analyzed using UPLC-Q-Exactive Orbitrap MS. Network pharmacology predicted the pharmacological basis and molecular mechanisms. Molecular docking experiments assessed the binding affinity of the identified compounds with target proteins. A total of 12 different and 65 common components were identified. Key therapeutic targets included SRC, STAT3, and PIK3CA, along with relevant signaling pathways linked to AS prevention. The study provides insights into interspecies differences in Dendrobium’s anti-AS properties. |
| format | Article |
| id | doaj-art-3aedb3fb388247f08b88da3ef8516be9 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-3aedb3fb388247f08b88da3ef8516be92025-01-19T12:40:11ZengNature Portfolionpj Science of Food2396-83702025-01-019111210.1038/s41538-025-00371-5Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MSYu Zhang0Xi Chen1Oushan Tang2Keyun Cheng3Lijun Ge4Weibo Lu5Jing Zheng6Yeshun Wu7Si-wei Wang8Xi-xi Zeng9Jing Xue10Yiwei Cui11Liting Ji12Qing Shen13Collaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang UniversityCenter for General Practice Medicine, Department of General Practice Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College) Department of Cardiology, The Second Hospital Affiliated to ShaoXing UniversitPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalCollaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang UniversityPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalCollaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollege of Biology and Environmental Engineering, Zhejiang Shuren UniversitySchool of Pharmaceutical Sciences, Zhejiang Chinese Medical UniversityPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalAbstract Atherosclerosis is a primary cause of cardiovascular disease, straining healthcare systems. Dendrobium officinale, a widely used food-medicine homology, has demonstrated anti-atherosclerotic (anti-AS) properties, with other species listed in pharmacopoeias exhibiting similar effects. However, their efficacy varies, and the impact of interspecies variations on compounds and mechanisms in Dendrobium’s anti-AS effects remains unclear. This study aimed to explore the anti-AS compounds and mechanisms across various Dendrobium species. The chemical composition of D. fimbriatum, D. officinale, D. devonianum, D. gratiosissimum, and D. catenatum was analyzed using UPLC-Q-Exactive Orbitrap MS. Network pharmacology predicted the pharmacological basis and molecular mechanisms. Molecular docking experiments assessed the binding affinity of the identified compounds with target proteins. A total of 12 different and 65 common components were identified. Key therapeutic targets included SRC, STAT3, and PIK3CA, along with relevant signaling pathways linked to AS prevention. The study provides insights into interspecies differences in Dendrobium’s anti-AS properties.https://doi.org/10.1038/s41538-025-00371-5 |
| spellingShingle | Yu Zhang Xi Chen Oushan Tang Keyun Cheng Lijun Ge Weibo Lu Jing Zheng Yeshun Wu Si-wei Wang Xi-xi Zeng Jing Xue Yiwei Cui Liting Ji Qing Shen Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS npj Science of Food |
| title | Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS |
| title_full | Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS |
| title_fullStr | Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS |
| title_full_unstemmed | Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS |
| title_short | Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS |
| title_sort | exploring similarities and differences in anti atherosclerotic potential bioactives among dendrobium species by uplc q exactive orbitrap ms |
| url | https://doi.org/10.1038/s41538-025-00371-5 |
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