Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization
Abstract Objectives This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer. Methods This study investigated genetic variants that have been associated with oral and oropharyngeal c...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01809-8 |
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| author | Sibo Xu Yiguo Li Wei Chen Ke Wang |
| author_facet | Sibo Xu Yiguo Li Wei Chen Ke Wang |
| author_sort | Sibo Xu |
| collection | DOAJ |
| description | Abstract Objectives This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer. Methods This study investigated genetic variants that have been associated with oral and oropharyngeal cancer using data from a large GWAS. Inflammatory cytokine data were obtained from 8293 asymptomatic individuals. The study primarily used inverse variance weighted and MR-Egger methods to determine the causal relationship between inflammatory cytokines and cancer incidence, complemented by a series of sensitivity analyses including MR-Egger, simple mode, weighted mode, weighted median and leave-one-out approaches. Results Our study demonstrates that higher levels of interleukin-7 (IL-7) and interleukin-5 (IL-5) slightly increase the odds of oropharyngeal cancer by 0.07% [OR: 1.0007, p = 0.005] and 0.04% [OR: 1.0004, p = 0.015], corresponding to a modest increase. Similarly, increased PDGF-bb and CTACK levels are modestly associated with increased odds of oral and oropharyngeal cancer by 0.22% [OR: 1.0022, p = 0.031] and 0.17% [OR: 1.0017, p = 0.043], respectively. Conclusion This investigation posits that IL-5 and IL-7 may be pertinent factors in the etiology of Oropharyngeal cancer, while PDGF bb and CTACK are likely implicated in the pathogenesis of both oral and oropharyngeal cancers. |
| format | Article |
| id | doaj-art-3ac9047304e04ece8b8ef96bd1f8e542 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-3ac9047304e04ece8b8ef96bd1f8e5422025-02-02T12:30:28ZengSpringerDiscover Oncology2730-60112025-01-0116111010.1007/s12672-025-01809-8Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomizationSibo Xu0Yiguo Li1Wei Chen2Ke Wang3Department of Stomatology, Hangzhou Linping District First People’s HospitalDepartment of Stomatology, Hangzhou Linping District First People’s HospitalDepartment of Stomatology, Hangzhou Linping District First People’s HospitalDepartment of Stomatology, Hangzhou Linping District First People’s HospitalAbstract Objectives This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer. Methods This study investigated genetic variants that have been associated with oral and oropharyngeal cancer using data from a large GWAS. Inflammatory cytokine data were obtained from 8293 asymptomatic individuals. The study primarily used inverse variance weighted and MR-Egger methods to determine the causal relationship between inflammatory cytokines and cancer incidence, complemented by a series of sensitivity analyses including MR-Egger, simple mode, weighted mode, weighted median and leave-one-out approaches. Results Our study demonstrates that higher levels of interleukin-7 (IL-7) and interleukin-5 (IL-5) slightly increase the odds of oropharyngeal cancer by 0.07% [OR: 1.0007, p = 0.005] and 0.04% [OR: 1.0004, p = 0.015], corresponding to a modest increase. Similarly, increased PDGF-bb and CTACK levels are modestly associated with increased odds of oral and oropharyngeal cancer by 0.22% [OR: 1.0022, p = 0.031] and 0.17% [OR: 1.0017, p = 0.043], respectively. Conclusion This investigation posits that IL-5 and IL-7 may be pertinent factors in the etiology of Oropharyngeal cancer, while PDGF bb and CTACK are likely implicated in the pathogenesis of both oral and oropharyngeal cancers.https://doi.org/10.1007/s12672-025-01809-8Oropharyngeal cancerBiomarkersMendelian randomizationGenome-wide association studies (GWAS)Inflammatory cytokines |
| spellingShingle | Sibo Xu Yiguo Li Wei Chen Ke Wang Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization Discover Oncology Oropharyngeal cancer Biomarkers Mendelian randomization Genome-wide association studies (GWAS) Inflammatory cytokines |
| title | Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization |
| title_full | Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization |
| title_fullStr | Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization |
| title_full_unstemmed | Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization |
| title_short | Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization |
| title_sort | investigating causal relationship among inflammatory cytokines and oropharyngeal cancer mendelian randomization |
| topic | Oropharyngeal cancer Biomarkers Mendelian randomization Genome-wide association studies (GWAS) Inflammatory cytokines |
| url | https://doi.org/10.1007/s12672-025-01809-8 |
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