LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma

LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma

Abstract While immune checkpoint inhibitors targeting programmed cell death-ligand 1 (PD-L1) demonstrate clinical efficacy in hepatocellular carcinoma (HCC), tumor cells frequently evade immune surveillance through PD-L1 overexpression, a phenomenon whose regulatory mechanisms remain poorly understo...

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Main Authors: Yuxuan Li, Jie Zhu, Fengguang Zhai, Yidong Ge, Ziqing Zhan, Shuyan Wang, Lili Kong, Jianan Zhao, Lecheng Hu, Siyuan Wang, Jiaxin Shi, Jianing Mao, Zongdong Yu, Haoyun Wang, Jiabei Jin, Mengxiang Zhao, Hong Li, Xiaofeng Jin
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02540-7
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https://doi.org/10.1038/s41420-025-02540-7

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