Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Abstract Osteoclasts (OCs) are bone-resorbing cells that originate from hematopoietic stem cells and develop through the fusion of mononuclear myeloid precursors. Dysregulation of OC development causes bone disorders such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Although the molecul...

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Bibliographic Details
Main Authors: Sung-Jin Bae, Min Wook Shin, Taekwon Son, Hye Shin Lee, Ji Soo Chae, Sejin Jeon, Goo Taeg Oh, Kyu-Won Kim
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0201-3
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