The role of the cytokines IL-27 and IL-35 in cancer
The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8$^+$ T cells are activated by IL-27 cytokine and...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1203 |
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| author | Avner Friedman Kang-Ling Liao |
| author_facet | Avner Friedman Kang-Ling Liao |
| author_sort | Avner Friedman |
| collection | DOAJ |
| description | The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8$^+$ T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8$^+$ T cells via TGF-$\beta$ production. Hence injections of IL-27 and anti-IL-35 are both potentially anti-tumor drugs.The models presented here are based on experimental mouse experiments, and their simulations agree with these experiments. The models are used to suggest effective schedules for drug treatment. |
| format | Article |
| id | doaj-art-3a58c10c41224aa195d0dbb67d2e83f8 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-3a58c10c41224aa195d0dbb67d2e83f82025-01-24T02:33:57ZengAIMS PressMathematical Biosciences and Engineering1551-00182015-07-011261203121710.3934/mbe.2015.12.1203The role of the cytokines IL-27 and IL-35 in cancerAvner Friedman0Kang-Ling Liao1Mathematical Biosciences Institute, The Ohio State University, Columbus, OH 43210Mathematical Biosciences Institute, The Ohio State University, Columbus, OHThe cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8$^+$ T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8$^+$ T cells via TGF-$\beta$ production. Hence injections of IL-27 and anti-IL-35 are both potentially anti-tumor drugs.The models presented here are based on experimental mouse experiments, and their simulations agree with these experiments. The models are used to suggest effective schedules for drug treatment.https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1203cancerinterleukin 27immune systeminterleukin 35. |
| spellingShingle | Avner Friedman Kang-Ling Liao The role of the cytokines IL-27 and IL-35 in cancer Mathematical Biosciences and Engineering cancer interleukin 27 immune system interleukin 35. |
| title | The role of the cytokines IL-27 and IL-35 in cancer |
| title_full | The role of the cytokines IL-27 and IL-35 in cancer |
| title_fullStr | The role of the cytokines IL-27 and IL-35 in cancer |
| title_full_unstemmed | The role of the cytokines IL-27 and IL-35 in cancer |
| title_short | The role of the cytokines IL-27 and IL-35 in cancer |
| title_sort | role of the cytokines il 27 and il 35 in cancer |
| topic | cancer interleukin 27 immune system interleukin 35. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1203 |
| work_keys_str_mv | AT avnerfriedman theroleofthecytokinesil27andil35incancer AT kanglingliao theroleofthecytokinesil27andil35incancer AT avnerfriedman roleofthecytokinesil27andil35incancer AT kanglingliao roleofthecytokinesil27andil35incancer |