$Discovery of thymol-fused chalcones as new competitive $\alpha$-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies$

Discovery of thymol-fused chalcones as new competitive $\alpha$-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies

This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11...

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Bibliographic Details
Main Authors:	Ade Danova, Elvira Hermawati, Warinthorn Chavasiri, Didin Mujahidin, Anita Alni, Robby Roswanda
Format:	Article
Language:	English
Published:	Komunitas Ilmuwan dan Profesional Muslim Indonesia 2024-12-01
Series:	Communications in Science and Technology
Subjects:	thymol chalcone diabetes mellitus molecular docking molecular dynamics $\alpha$-glucosidase
Online Access:	https://cst.kipmi.or.id/journal/article/view/1497
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Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies

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