CDK4/6 inhibitors synergize with radiotherapy to prime the tumor microenvironment and enhance the antitumor effect of anti-PD-L1 immunotherapy in triple-negative breast cancer

CDK4/6 inhibitors synergize with radiotherapy to prime the tumor microenvironment and enhance the antitumor effect of anti-PD-L1 immunotherapy in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) has the highest mortality rate among all breast cancer subtypes. Although immunotherapy shows promise, its efficacy varies. CDK4/6 inhibitors can radiosensitize and modulate the immune system, and high-dose radiotherapy (RT) can enhance the ef...

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Bibliographic Details
Main Authors: Wen-Chi Yang, Ming-Feng Wei, Ying-Chun Shen, Chiun-Sheng Huang, Sung-Hsin Kuo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
CDK4/6 inhibitor
Radiotherapy
Immunotherapy
Online Access:https://doi.org/10.1186/s12929-025-01173-3
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https://doi.org/10.1186/s12929-025-01173-3

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