Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress

Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress

Abstract Thermogenic proteins are down-regulated under thermal stress, including PGC1α· However, the molecular mechanisms are not fully understood. Here, we addressed that chaperone-mediated autophagy could regulate the stability of PGC1α under thermal stress. In mice, knockdown of Lamp2a, one of th...

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Main Authors: Yixiao Zhuang, Xinyi Zhang, Shuang Zhang, Yunpeng Sun, Hui Wang, Yuxuan Chen, Hanyin Zhang, Penglai Zou, Yonghao Feng, Xiaodan Lu, Peijie Chen, Yi Xu, John Zhong Li, Huanqing Gao, Li Jin, Xingxing Kong
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59618-0
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https://doi.org/10.1038/s41467-025-59618-0

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