Extracellular matrix stiffness regulates colorectal cancer progression via HSF4

Extracellular matrix stiffness regulates colorectal cancer progression via HSF4

Abstract Background Colorectal cancer (CRC) has high incidence and mortality rates, with severe prognoses during invasion and metastasis stages. Despite advancements in diagnostic and therapeutic technologies, the impact of the tumour microenvironment, particularly extracellular matrix (ECM) stiffne...

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Bibliographic Details
Main Authors: Kangtao Wang, Siyi Ning, Shuai Zhang, Mingming Jiang, Yan Huang, Haiping Pei, Ming Li, Fengbo Tan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Tumour stiffness
Magnetic resonance elastography
Heat shock transcriptional factor 4
Extracellular matrix
Transcriptome sequencing
Online Access:https://doi.org/10.1186/s13046-025-03297-8
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https://doi.org/10.1186/s13046-025-03297-8

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