Circulating T cell status and molecular imaging may predict clinical benefit of neoadjuvant PD-1 blockade in oral cancer

Circulating T cell status and molecular imaging may predict clinical benefit of neoadjuvant PD-1 blockade in oral cancer

Background Addition of neoadjuvant immune checkpoint inhibition to standard-of-care interventions for locally advanced oral cancer could improve clinical outcome.Methods In this study, 16 evaluable patients with stage III/IV oral cancer were treated with one dose of 480 mg nivolumab 3 weeks prior to...

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Main Authors: Tanja D de Gruijl, Rieneke van de Ven, K Hakki Karagozoglu, Pim de Graaf, Ronald Boellaard, Ruud H Brakenhoff, C René Leemans, Gerben J C Zwezerijnen, C Willemien Menke-van der Houven van Oordt, Iris H C Miedema, Niels E Wondergem, Jan-Jaap Hendrickx, Simone E J Eerenstein, Rolf J Bun, Dorien C Mulder, Jens Voortman, Albert D Windhorst, J Pascal Hagers, Laura A N Peferoen, Elisabeth Bloemena
Format: Article
Language:English
Published: BMJ Publishing Group 2024-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/7/e009278.full
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https://jitc.bmj.com/content/12/7/e009278.full

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