A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome

A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome

Abstract Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (FIO2) in patients with acute respiratory distress syndrome (ARDS). Atelectasis, which is commonly observed in ARDS, not only l...

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Bibliographic Details
Main Authors: Kentaro Tojo, Takuya Yazawa
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Oxygen
Acute respiratory distress syndrome
Atelectasis
Alveolar hypoxia
Hypoxia-induced inflammation
Online Access:https://doi.org/10.1038/s41598-024-83992-2
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https://doi.org/10.1038/s41598-024-83992-2

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