Synthesis and pharmacological properties of novel guanidine derivatives of quinazoline-2,4(1H,3H)-dione

Synthesis and pharmacological properties of novel guanidine derivatives of quinazoline-2,4(1H,3H)-dione

Introduction: Na+/H+ exchanger type 1 (NHE-1) is a validated drug target for the treatment of cardiovascular and ophthalmic diseases due to the cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. This article presents data on the synthesis and pharmacological activity...

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Main Authors: Alexander A. Ozerov, Daria V. Merezhkina, Natalia A. Gurova, Lyudmila V. Naumenko, Denis A. Babkov, Victor S. Sirotenko, Roman A. Litvinov, Alena S. Taran, Nadezhda V. Stepanova, Umida M. Ibragimova, Alexander A. Spasov, Vadim A. Kosolapov
Format: Article
Language:English
Published: Belgorod National Research University 2024-09-01
Series:Research Results in Pharmacology
Subjects:
na /h -exchanger
nhe-1
guanidine derivatives of quinazoline
antiglaucomic action
antiglycation
antiplatelet activity
Online Access:https://rrpharmacology.ru/index.php/journal/article/view/486
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