Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study
Abstract Background In this study, we aimed to explore the association between baseline and early changes in the neutrophil-to-lymphocyte ratio (NLR) and the 30-day mortality rate in patients having anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis with interstitial lun...
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2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03512-4 |
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| author | Hongxia Xin Ping He Bin Xi Zhaojun Wang Han Wang Faxuan Wang Zhanbing Ma Jing Xue Yuanyuan Jia Hourong Cai Bi Chen Juan Chen |
| author_facet | Hongxia Xin Ping He Bin Xi Zhaojun Wang Han Wang Faxuan Wang Zhanbing Ma Jing Xue Yuanyuan Jia Hourong Cai Bi Chen Juan Chen |
| author_sort | Hongxia Xin |
| collection | DOAJ |
| description | Abstract Background In this study, we aimed to explore the association between baseline and early changes in the neutrophil-to-lymphocyte ratio (NLR) and the 30-day mortality rate in patients having anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis with interstitial lung disease (DM-ILD). Methods Overall, 263 patients with anti-MDA5 DM-ILD from four centers in China were analyzed. Multivariate logistic regression analysis was used to evaluate the impact of baseline NLR on the 30-day mortality rate in patients with anti-MDA5-positive DM-ILD. Furthermore, a generalized additive mixed model (GAMM) was applied to compare the NLR variations over time between 30-day survival group and non-survival group. Results Two hundred sixty-three patients with anti-MDA5-positive DM-ILD were divided into different groups based on their NLR and whether they survived or not within 30 days. The multivariate logistic regression analysis, accounting for confounding factors, identified an elevated baseline NLR as a prognostic indicator for 30-day mortality in patients with anti-MDA5-positive DM-ILD (hazard ratio 2.68, 95% confidence interval [CI] 1.18,6.00, P = 0.019). Furthermore, the GAMM results indicated that the NLR gradually increased more in the non-survival group compared with the survival group within 14 days of admission, with a daily average increase of 1.03 (β = 1.03; 95% CI, 0.75–1.31; P < 0.001). Conclusions We found that an elevated baseline NLR and its progressive increase are associated with 30-day mortality in patients with anti-MDA5-positive DM-ILD. |
| format | Article |
| id | doaj-art-39f7c57928bb4d48a6a4f8ae35b16bd8 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-39f7c57928bb4d48a6a4f8ae35b16bd82025-01-26T12:13:08ZengBMCBMC Pulmonary Medicine1471-24662025-01-012511810.1186/s12890-025-03512-4Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective studyHongxia Xin0Ping He1Bin Xi2Zhaojun Wang3Han Wang4Faxuan Wang5Zhanbing Ma6Jing Xue7Yuanyuan Jia8Hourong Cai9Bi Chen10Juan Chen11Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical UniversityDepartment of Respiratory and Critical Care Medicine, the Third People’s Hospital of ChengduDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical UniversityDepartment of Intensive Care Unit, General Hospital of Ningxia Medical University, Yinchuan School of Information Science and Technology, Institute of Computational Biology, Northeast Normal UniversitySchool of Public Health, Ningxia Medical UniversityDepartment of Medical Genetics and Cell Biology, College of Basic Medicine, Ningxia Medical UniversityDepartment of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical UniversityDepartment of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical UniversityDepartment of Respiratory Medicine, Nanjing Drum Tower HospitalDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical UniversityDepartment of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical UniversityAbstract Background In this study, we aimed to explore the association between baseline and early changes in the neutrophil-to-lymphocyte ratio (NLR) and the 30-day mortality rate in patients having anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis with interstitial lung disease (DM-ILD). Methods Overall, 263 patients with anti-MDA5 DM-ILD from four centers in China were analyzed. Multivariate logistic regression analysis was used to evaluate the impact of baseline NLR on the 30-day mortality rate in patients with anti-MDA5-positive DM-ILD. Furthermore, a generalized additive mixed model (GAMM) was applied to compare the NLR variations over time between 30-day survival group and non-survival group. Results Two hundred sixty-three patients with anti-MDA5-positive DM-ILD were divided into different groups based on their NLR and whether they survived or not within 30 days. The multivariate logistic regression analysis, accounting for confounding factors, identified an elevated baseline NLR as a prognostic indicator for 30-day mortality in patients with anti-MDA5-positive DM-ILD (hazard ratio 2.68, 95% confidence interval [CI] 1.18,6.00, P = 0.019). Furthermore, the GAMM results indicated that the NLR gradually increased more in the non-survival group compared with the survival group within 14 days of admission, with a daily average increase of 1.03 (β = 1.03; 95% CI, 0.75–1.31; P < 0.001). Conclusions We found that an elevated baseline NLR and its progressive increase are associated with 30-day mortality in patients with anti-MDA5-positive DM-ILD.https://doi.org/10.1186/s12890-025-03512-4Anti-MDA5DermatomyositisInterstitial lung diseaseNeutrophil-to-lymphocyte ratio |
| spellingShingle | Hongxia Xin Ping He Bin Xi Zhaojun Wang Han Wang Faxuan Wang Zhanbing Ma Jing Xue Yuanyuan Jia Hourong Cai Bi Chen Juan Chen Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study BMC Pulmonary Medicine Anti-MDA5 Dermatomyositis Interstitial lung disease Neutrophil-to-lymphocyte ratio |
| title | Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study |
| title_full | Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study |
| title_fullStr | Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study |
| title_short | Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study |
| title_sort | neutrophil to lymphocyte ratio and short term mortality in patients having anti mda5 positive dermatomyositis with interstitial lung disease a retrospective study |
| topic | Anti-MDA5 Dermatomyositis Interstitial lung disease Neutrophil-to-lymphocyte ratio |
| url | https://doi.org/10.1186/s12890-025-03512-4 |
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