Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD

Abstract Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the most applied targeted therapy for EGFR-mutant lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, osimertinib, is widely used throughout lung cancer treatment, with single or combination modes. One of t...

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Bibliographic Details
Main Authors: Mingxin Liu, Bo Tang, Run Xiang, Peihong Hu, Chuan Xu, Lanlin Hu, Qiang Li
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Discover Oncology
Subjects:
Online Access:https://doi.org/10.1007/s12672-024-01552-6
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