Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice
Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis. This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet (HFD)-induced obesity. The re...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2019-12-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019302071 |
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| author | Jia-Ni Lin Pei-Sheng Lee Nai-Wen Mei An-Chin Cheng Roch-Chui Yu Min-Hsiung Pan |
| author_facet | Jia-Ni Lin Pei-Sheng Lee Nai-Wen Mei An-Chin Cheng Roch-Chui Yu Min-Hsiung Pan |
| author_sort | Jia-Ni Lin |
| collection | DOAJ |
| description | Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis. This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet (HFD)-induced obesity. The results showed that HFD treatment influenced body weight gain, adipose tissue accumulation and biochemical parameter changes. Compared to the HFD group, ginseng supplementation of HFD-fed mice decreased body weight, adipose tissue mass, total cholesterol (T-CHO) and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) ratio. To analysis the alterations of gut microbiota, ginseng in dietary supplements decreased Firmicutes abundance and increased Bacteroidetes abundance. Taken together, these findings suggest ginseng may modulate the energy storage and alter gut microbiota composition. Keywords: Ginseng, High-fat diet, Obesity, Gut microbiota |
| format | Article |
| id | doaj-art-39ed420247f547ccb67beb80d12c5b1f |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-39ed420247f547ccb67beb80d12c5b1f2025-02-03T06:47:51ZengTsinghua University PressFood Science and Human Wellness2213-45302019-12-0184344350Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 MiceJia-Ni Lin0Pei-Sheng Lee1Nai-Wen Mei2An-Chin Cheng3Roch-Chui Yu4Min-Hsiung Pan5Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ChinaInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ChinaGINCARE Int'l Enterprises Co., Ltd., No. 24, Sec. 3, Chungyang Rd., Tu-Cheng Dist., New Taipei City, 23673, Taiwan, ChinaDepartment of Tourism, Food and Beverage Management, Chang Jung Christian University, Tainan 71101, Taiwan, ChinaInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ChinaInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, China; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, China; Corresponding author at: Institute of Food Science and Technology, National Taiwan University, 1, Sec. 4, Roosevelt Rd., Taipei, 106, Taiwan, China.Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis. This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet (HFD)-induced obesity. The results showed that HFD treatment influenced body weight gain, adipose tissue accumulation and biochemical parameter changes. Compared to the HFD group, ginseng supplementation of HFD-fed mice decreased body weight, adipose tissue mass, total cholesterol (T-CHO) and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) ratio. To analysis the alterations of gut microbiota, ginseng in dietary supplements decreased Firmicutes abundance and increased Bacteroidetes abundance. Taken together, these findings suggest ginseng may modulate the energy storage and alter gut microbiota composition. Keywords: Ginseng, High-fat diet, Obesity, Gut microbiotahttp://www.sciencedirect.com/science/article/pii/S2213453019302071 |
| spellingShingle | Jia-Ni Lin Pei-Sheng Lee Nai-Wen Mei An-Chin Cheng Roch-Chui Yu Min-Hsiung Pan Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice Food Science and Human Wellness |
| title | Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice |
| title_full | Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice |
| title_fullStr | Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice |
| title_full_unstemmed | Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice |
| title_short | Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice |
| title_sort | effects of ginseng dietary supplementation on a high fat diet induced obesity in c57bl 6 mice |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019302071 |
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