The Spread of Antibiotic Resistance Genes In Vivo Model
Infections caused by antibiotic-resistant bacteria are a major public health threat. The emergence and spread of antibiotic resistance genes (ARGs) in the environment or clinical setting pose a serious threat to human and animal health worldwide. Horizontal gene transfer (HGT) of ARGs is one of the...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2022/3348695 |
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| _version_ | 1832563483377401856 |
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| author | Shuan Tao Huimin Chen Na Li Tong Wang Wei Liang |
| author_facet | Shuan Tao Huimin Chen Na Li Tong Wang Wei Liang |
| author_sort | Shuan Tao |
| collection | DOAJ |
| description | Infections caused by antibiotic-resistant bacteria are a major public health threat. The emergence and spread of antibiotic resistance genes (ARGs) in the environment or clinical setting pose a serious threat to human and animal health worldwide. Horizontal gene transfer (HGT) of ARGs is one of the main reasons for the dissemination of antibiotic resistance in vitro and in vivo environments. There is a consensus on the role of mobile genetic elements (MGEs) in the spread of bacterial resistance. Most drug resistance genes are located on plasmids, and the spread of drug resistance genes among microorganisms through plasmid-mediated conjugation transfer is the most common and effective way for the spread of multidrug resistance. Experimental studies of the processes driving the spread of antibiotic resistance have focused on simple in vitro model systems, but the current in vitro protocols might not correctly reflect the HGT of antibiotic resistance genes in realistic conditions. This calls for better models of how resistance genes transfer and disseminate in vivo. The in vivo model can better mimic the situation that occurs in patients, helping study the situation in more detail. This is crucial to develop innovative strategies to curtail the spread of antibiotic resistance genes in the future. This review aims to give an overview of the mechanisms of the spread of antibiotic resistance genes and then demonstrate the spread of antibiotic resistance genes in the in vivo model. Finally, we discuss the challenges in controlling the spread of antibiotic resistance genes and their potential solutions. |
| format | Article |
| id | doaj-art-39d8f9075f6140f8bfc2fd8d586b49c7 |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-39d8f9075f6140f8bfc2fd8d586b49c72025-02-03T01:20:07ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932022-01-01202210.1155/2022/3348695The Spread of Antibiotic Resistance Genes In Vivo ModelShuan Tao0Huimin Chen1Na Li2Tong Wang3Wei Liang4School of MedicalSchool of MedicalBengbu Medical CollegeNanjing Brain Hospital Affiliated Nanjing Medical UniversityLianyungang Clinical College of Jiangsu UniversityInfections caused by antibiotic-resistant bacteria are a major public health threat. The emergence and spread of antibiotic resistance genes (ARGs) in the environment or clinical setting pose a serious threat to human and animal health worldwide. Horizontal gene transfer (HGT) of ARGs is one of the main reasons for the dissemination of antibiotic resistance in vitro and in vivo environments. There is a consensus on the role of mobile genetic elements (MGEs) in the spread of bacterial resistance. Most drug resistance genes are located on plasmids, and the spread of drug resistance genes among microorganisms through plasmid-mediated conjugation transfer is the most common and effective way for the spread of multidrug resistance. Experimental studies of the processes driving the spread of antibiotic resistance have focused on simple in vitro model systems, but the current in vitro protocols might not correctly reflect the HGT of antibiotic resistance genes in realistic conditions. This calls for better models of how resistance genes transfer and disseminate in vivo. The in vivo model can better mimic the situation that occurs in patients, helping study the situation in more detail. This is crucial to develop innovative strategies to curtail the spread of antibiotic resistance genes in the future. This review aims to give an overview of the mechanisms of the spread of antibiotic resistance genes and then demonstrate the spread of antibiotic resistance genes in the in vivo model. Finally, we discuss the challenges in controlling the spread of antibiotic resistance genes and their potential solutions.http://dx.doi.org/10.1155/2022/3348695 |
| spellingShingle | Shuan Tao Huimin Chen Na Li Tong Wang Wei Liang The Spread of Antibiotic Resistance Genes In Vivo Model Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | The Spread of Antibiotic Resistance Genes In Vivo Model |
| title_full | The Spread of Antibiotic Resistance Genes In Vivo Model |
| title_fullStr | The Spread of Antibiotic Resistance Genes In Vivo Model |
| title_full_unstemmed | The Spread of Antibiotic Resistance Genes In Vivo Model |
| title_short | The Spread of Antibiotic Resistance Genes In Vivo Model |
| title_sort | spread of antibiotic resistance genes in vivo model |
| url | http://dx.doi.org/10.1155/2022/3348695 |
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